Browsing: cofactorrefreshing

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Non-invasive continuous lipid profiling via cofactor-refreshing cascading enzymatic reactions and causal machine learning

Continuous lipid profiling could reveal dynamic lipid fluctuations underlying cardiometabolic health, yet existing enzymatic sensing strategies cannot sustain the multi-enzyme reactions required for continuous lipid detection, particularly when non-regenerable cofactors are consumed. Here we introduce a wearable epidermal lipid profiler for non-invasive, continuous monitoring of cholesterol and triglycerides using dual-step and cascading enzymatic reactions supported…